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KMID : 1214920160220010016
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Soonchunhyang Medical Science
2016 Volume.22 No. 1 p.16 ~ p.22
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Risk Factors of Recurrent Kawasaki Disease
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Kim Shin-Ah
Park Min-Jee
Jin Jang-Yong
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Abstract
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Objective: This study looks into the risk factors that affect the recurrence of Kawasaki disease (KD).
Methods: Among 618 child patients that have been hospitalized for the KD from July 2002 to May 2015 at the Soonchunhyang University Bucheon Hospital, 13 patients who have been hospitalized more than twice for the KD were selected as the relapse group. A comparative analysis was retrospectively conducted between the relapse group and the control group.
Results: Among 618 child patients with KD, 13 cases (2.1%) showed recurrence in the disease. At initial episode of the relapse group, the mean age was 29±14.2 months. One year or less and 1-2 years old took up 76.8%, and 11 patients (84.6%) suffered a recurrence within 2 years after the initial episode. The relapse group, when compared to the control group, showed lower neutrophils count, and red cell distribution width (RDW) and C-reactive protein (CRP) levels were higher at initial episode. These differences were statistically significant (P<0.001, P<0.001, and P=0.015, respectively). There were no differences in other findings between the two groups. By utilizing the Youden’s index, the optimal cutoff value was found, and RDW was 12% and CRP was 5.955 mg/dL.
Conclusion: The research suggests that it is possible to predict recurrence probabilities of KD by checking RDW and CRP values during blood tests at initial episode. Children less than 1 year old and 1-2 years old with Kawasaki disease should be carefully observed for recurrence during the 2 years after the initial episode.
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KEYWORD
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Recurrence, Mucocutaneous lymph node syndrome, Erythrocyte indices, C-reactive protein
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